India’s recent Nipah virus (NiV) outbreak has triggered global alarm, prompting neighboring countries like Thailand and Nepal to enhance health screening measures for travelers from India. The World Health Organization (WHO) classifies Nipah as a highly lethal zoonotic virus, primarily hosted by fruit bats. Transmissible via contaminated food or direct human contact, NiV boasts a staggering 40%–75% fatality rate.
With an incubation period of 4–14 days (up to 45 days in rare cases), Nipah has caused recurrent outbreaks since its debut in Malaysia and Singapore (1998–1999), later striking India, Bangladesh, and the Philippines—inflicting severe public health and agricultural losses. No approved vaccines or treatments exist, making early, precise detection critical for containment.
To combat this high-risk emerging pathogen, East & West Analytical Instruments Inc.（EWAI）introduces its Nipah Virus 7-plex PCR-MS Detection System, offering three key advantages over conventional PCR:
1.Ultra Accuracy:Multi-target PCR coupled with label-free mass spectrometry eliminates cross-talk artifacts from fluorescent probes (common in multiplex qPCR), reducing false positives.
2.High Sensitivity: Detects NiV even in degraded samples.
3.Swift Traceability: SNP-based analysis pinpoints two major strains—Malaysian (NC_002728) and Bangladeshi (AY988601)—delivering actionable data for surveillance and outbreak tracing.No specialized sequencing required.
1.Comprehensive Targets: Virus Detection + Quality Control
6 core NiV genes (N, P, M, F, G, L) covering structural/functional regions
Human DNA internal control ensures sample integrity and process reliability
2.Superior Strain Differentiation for Precision Epidemiology
Enabled by high-resolution SNP profiling, the platform:
Generates high-fidelity sequence data
Supports detailed phylogenetic comparisons
Accurately distinguishes:
Malaysian strain (NC_002728)&Bangladeshi strain (AY988601)
Providing molecular evidence for transmission chains and risk assessment.
3. Key Technical Advantages
7-plex detection: Multi-target screening in a single run
Dual validation: PCR + MS for maximum specificity
Strain typing & evolutionary analysis
High sensitivity/accuracy: Ideal for early screening and challenging samples
Robust internal controls: Ensures reproducible results
Conclusion: Faster Than the Virus Itself
From COVID-19 in 2020 to African Swine Fever and NiV, and future emerging threats—EWAI’s decade-deep expertise in mass spectrometry technology proves one thing: In the race against viral evolution, detection must outpace outbreaks.
